Promethazine

Generic Name
Promethazine
Brand Names
Phenadoz, Phenergan, Promethazine DM, Promethegan
Drug Type
Small Molecule
Chemical Formula
C17H20N2S
CAS Number
60-87-7
Unique Ingredient Identifier
FF28EJQ494
Background

Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.
...

Indication

Promethazine tablets and suppositories are indicated to treat rhinitis, allergic conjunctivitis, allergic reactions to blood or plasma, dermographism, anaphylactic reactions, sedation, nausea, vomiting, pain, motion sickness, and allergic skin reactions. Promethazine cough syrup with phenylephrine and codeine is indicated to relieve cough and upper respirato...

Associated Conditions
Allergic Conjunctivitis (AC), Allergic urticaria, Anaphylaxis, Cough, Dermographism, Motion Sickness, Nasal Congestion, Postoperative pain, Seasonal Allergic Rhinitis, Vasomotor Rhinitis, Acute Allergic Reactions, Dry cough, Perioperative nausea and vomiting, Upper respiratory symptoms
Associated Therapies
Sedative therapy, Adjunct to anesthesia and analgesia therapy
Clinical Trials
Related News

Treatment of Pruritus With Intramuscular Promethazine

Phase 4
Completed
Conditions
Pruritus
Pregnancy Related
Interventions
Drug: Placebo
Drug: Promethazine
First Posted Date
2021-03-18
Last Posted Date
2024-08-15
Lead Sponsor
University of Florida
Target Recruit Count
110
Registration Number
NCT04805073
Locations
🇺🇸

UF Health at the University of Florida, Gainesville, Florida, United States

Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

First Posted Date
2016-05-06
Last Posted Date
2024-02-06
Lead Sponsor
University of Pennsylvania
Target Recruit Count
8
Registration Number
NCT02765256
Locations
🇺🇸

University of Pennsylvania, Philadelphia, Pennsylvania, United States

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable
Completed
Conditions
Postoperative Nausea and Vomiting
Interventions
Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron
First Posted Date
2015-12-09
Last Posted Date
2019-03-07
Lead Sponsor
Vanderbilt University
Target Recruit Count
27034
Registration Number
NCT02625181
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels

First Posted Date
2014-05-13
Last Posted Date
2018-01-08
Lead Sponsor
Faisal_Karmali@MEEI.HARVARD.EDU
Target Recruit Count
30
Registration Number
NCT02136420
Locations
🇺🇸

Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States

Study of Promethazine for Treatment of Diabetic Gastroparesis

Phase 2
Terminated
Conditions
Diabetic Gastroparesis
Interventions
Drug: Promethazine
Drug: Sugar pill
First Posted Date
2014-05-05
Last Posted Date
2018-08-07
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
3
Registration Number
NCT02130622
Locations
🇺🇸

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects

First Posted Date
2013-05-03
Last Posted Date
2016-10-24
Lead Sponsor
Indivior Inc.
Target Recruit Count
43
Registration Number
NCT01846455
Locations
🇺🇸

Clinical Pharmacology of Miami, Inc., Hialeah, Florida, United States

🇺🇸

Orlando Clinical Research Center, Orlando, Florida, United States

🇺🇸

American Research Corporation (ARC), San Antonio, Texas, United States

Promethazine vs. Lorazepam for Treatment of Vertigo

Phase 3
Completed
Conditions
Peripheral Vertigo.
Interventions
Drug: Promethazine
Drug: Lorazepam
First Posted Date
2013-04-09
Last Posted Date
2013-06-14
Lead Sponsor
Shahid Beheshti University of Medical Sciences
Target Recruit Count
210
Registration Number
NCT01827293
Locations
🇮🇷

Department of Neurology, Emam Hossein Hospital, Tehran, Nezam Abad, Iran, Islamic Republic of

Effect of Hyoscine and Promethazine on Labor Pain

Phase 2
Completed
Conditions
Labor Pain
Interventions
Drug: Promethazine
Drug: Hyoscine
First Posted Date
2012-07-19
Last Posted Date
2012-07-20
Lead Sponsor
Mashhad University of Medical Sciences
Target Recruit Count
93
Registration Number
NCT01644838

Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting

First Posted Date
2011-11-18
Last Posted Date
2013-12-03
Lead Sponsor
Sergio Bergese
Target Recruit Count
122
Registration Number
NCT01474915
Locations
🇺🇸

The Ohio State University Wexner Medical Center, Columbus, Ohio, United States

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